:root {
  --ink: #142127;
  --muted: #5f6969;
  --paper: #f4f3ef;
  --white: #fff;
  --green: #075c47;
  --green-deep: #063c32;
  --mint: #d9eee5;
  --gold: #b68a42;
  --rose: #bc5b52;
  --line: rgba(20, 33, 39, 0.16);
  --max: 1180px;
}

* { box-sizing: border-box; }
html { scroll-behavior: smooth; }
body {
  margin: 0;
  color: var(--ink);
  background: var(--paper);
  font-family: "Hiragino Kaku Gothic ProN", "Yu Gothic", "Noto Sans JP", sans-serif;
  line-height: 1.8;
  letter-spacing: 0;
}
img { display: block; max-width: 100%; }
a { color: inherit; }
button, input { font: inherit; }

.skip-link {
  position: fixed;
  z-index: 100;
  top: 8px;
  left: 8px;
  padding: 8px 12px;
  color: var(--white);
  background: var(--green);
  transform: translateY(-150%);
}
.skip-link:focus { transform: none; }

.site-header {
  position: absolute;
  z-index: 10;
  top: 0;
  left: 0;
  display: grid;
  grid-template-columns: 180px 1fr auto;
  align-items: center;
  width: 100%;
  min-height: 84px;
  padding: 14px clamp(20px, 4vw, 64px);
  color: var(--white);
  border-bottom: 1px solid rgba(255,255,255,.24);
}
.brand {
  display: inline-flex;
  align-items: center;
  gap: 10px;
  width: max-content;
  color: var(--white);
  text-decoration: none;
}
.brand img { width: 42px; height: 42px; object-fit: contain; }
.brand-type { display: grid; gap: 3px; line-height: 1; }
.brand-type strong { font: 500 12px/1 Arial, sans-serif; }
.brand-type small { color: #d8b877; font: 700 7px/1 Arial, sans-serif; }
.series-mark { margin: 0; text-align: center; font: 700 12px/1.4 Arial, sans-serif; }
.series-mark span { margin-right: 12px; font-family: inherit; font-weight: 500; }
.header-cta {
  padding: 8px 0;
  font-size: 13px;
  font-weight: 700;
  text-decoration: none;
  border-bottom: 1px solid currentColor;
}

.hero {
  position: relative;
  display: flex;
  align-items: flex-end;
  min-height: min(860px, 92svh);
  overflow: hidden;
  color: var(--white);
  background: #14181d;
}
.hero-media, .hero-shade { position: absolute; inset: 0; }
.hero-media img { width: 100%; height: 100%; object-fit: cover; object-position: 50% 53%; }
.hero-shade { background: linear-gradient(90deg, rgba(8,15,18,.9) 0%, rgba(8,15,18,.6) 42%, rgba(8,15,18,.08) 78%), linear-gradient(0deg, rgba(8,15,18,.72), transparent 45%); }
.hero-copy {
  position: relative;
  z-index: 1;
  width: min(900px, 88%);
  margin: 0 0 clamp(70px, 10vh, 112px) max(24px, calc((100vw - var(--max)) / 2));
  padding-right: 24px;
}
.eyebrow {
  margin: 0 0 18px;
  color: #d8ebdf;
  font-size: 12px;
  font-weight: 700;
  letter-spacing: 0;
}
.eyebrow::before { content: ""; display: inline-block; width: 28px; height: 1px; margin: 0 10px 4px 0; background: currentColor; }
.eyebrow.dark { color: var(--green); }
.hero h1 {
  margin: 0;
  font-size: clamp(34px, 4.5vw, 64px);
  font-weight: 500;
  line-height: 1.35;
}
.hero h1 strong { color: #f4d28f; font-weight: 700; }
.hero-lead { margin: 24px 0 28px; font-size: clamp(15px, 1.4vw, 19px); }
.text-link { display: inline-flex; gap: 28px; align-items: center; padding: 9px 0; font-size: 14px; font-weight: 700; text-decoration: none; border-bottom: 1px solid rgba(255,255,255,.7); }
.concept-label { position: absolute; right: 24px; bottom: 20px; z-index: 1; margin: 0; font-size: 10px; opacity: .7; }
.mobile-only { display: none; }

.section-inner { width: min(var(--max), calc(100% - 48px)); margin: 0 auto; }
.section-number { margin: 0 0 28px; color: var(--gold); font: 700 11px/1.2 Arial, sans-serif; }
.section-number.light { color: #bddfcf; }
h2 { margin: 0; font-size: clamp(30px, 4vw, 52px); line-height: 1.45; font-weight: 600; }
h2 em { color: var(--rose); font-style: normal; }

.answer-band { padding: clamp(72px, 10vw, 132px) 0; background: var(--white); }
.answer-grid { display: grid; grid-template-columns: minmax(0, 1.35fr) minmax(300px, .65fr); gap: clamp(48px, 8vw, 110px); align-items: end; }
.answer-note { padding-bottom: 8px; }
.answer-note > p { margin: 0 0 28px; color: var(--muted); }
.not-list { display: flex; flex-wrap: wrap; gap: 8px; }
.not-list span { padding: 5px 10px; color: #753e39; background: #f5e6e3; font-size: 12px; }
.not-list span::before { content: "×"; margin-right: 5px; font-weight: 700; }

.split-section { display: grid; grid-template-columns: minmax(360px, .9fr) minmax(420px, 1.1fr); min-height: 780px; }
.image-frame { position: relative; overflow: hidden; background: #11181b; }
.split-media img { width: 100%; height: 100%; object-fit: cover; object-position: 50% 50%; }
.image-frame > span { position: absolute; right: 18px; bottom: 14px; padding: 2px 6px; color: rgba(255,255,255,.8); background: rgba(0,0,0,.36); font-size: 10px; }
.split-copy { display: flex; flex-direction: column; justify-content: center; padding: clamp(64px, 8vw, 120px); background: #e5eee9; }
.split-copy > p:not(.section-number,.eyebrow) { max-width: 650px; margin: 28px 0 34px; color: var(--muted); }
.definition-list { margin: 0; border-top: 1px solid var(--line); }
.definition-list div { display: grid; grid-template-columns: 70px 1fr; gap: 22px; padding: 16px 0; border-bottom: 1px solid var(--line); }
.definition-list dt { color: var(--green); font-weight: 700; }
.definition-list dd { margin: 0; color: var(--muted); font-size: 14px; }

.inflammation-section { padding: clamp(72px, 10vw, 128px) 0; color: var(--white); background: #10211f; }
.inflammation-grid { display: grid; grid-template-columns: .72fr 1.28fr; gap: clamp(48px, 8vw, 110px); align-items: center; }
.inflammation-copy p:last-child { margin-top: 30px; color: #b8c7c3; }
.inflammation-figure { margin: 0; }
.inflammation-figure img { width: 100%; max-height: 620px; object-fit: cover; object-position: 50% 50%; }
.inflammation-figure figcaption { margin-top: 14px; color: #aab9b5; font-size: 12px; }
.inflammation-figure figcaption span { display: inline-block; width: 7px; height: 7px; margin-right: 7px; background: #df7469; border-radius: 50%; }

.evidence-section { padding: clamp(72px, 11vw, 140px) 0; background: var(--paper); }
.section-heading { display: grid; grid-template-columns: .7fr 1.3fr; gap: 40px; align-items: end; margin-bottom: 64px; }
.evidence-table { border-top: 2px solid var(--ink); }
.evidence-row { display: grid; grid-template-columns: 1fr 1.5fr .55fr; gap: 30px; align-items: center; min-height: 116px; padding: 22px 4px; border-bottom: 1px solid var(--line); }
.evidence-head { min-height: 44px; padding: 10px 4px; color: var(--muted); font-size: 11px; font-weight: 700; }
.evidence-row strong { font-size: 16px; }
.evidence-row strong small { display: block; margin-bottom: 4px; color: var(--gold); font: 700 10px/1.2 Arial, sans-serif; }
.evidence-row > span:nth-child(2) { color: var(--muted); font-size: 14px; }
.evidence-tag { justify-self: start; padding: 5px 10px; font-size: 11px; font-weight: 700; }
.evidence-tag.established { color: #235243; background: var(--mint); }
.evidence-tag.research { color: #745316; background: #f4e7c8; }
.evidence-footnote { max-width: 790px; margin: 28px 0 0 auto; color: var(--muted); font-size: 12px; }

.pathway-section { display: grid; grid-template-columns: 1fr 1fr; background: var(--white); }
.pathway-image { min-height: 800px; }
.pathway-image img { width: 100%; height: 100%; object-fit: cover; }
.pathway-copy { padding: clamp(64px, 8vw, 118px); }
.steps { margin: 48px 0 0; padding: 0; list-style: none; border-top: 1px solid var(--line); }
.steps li { display: grid; grid-template-columns: 34px 1fr; gap: 18px; padding: 20px 0; border-bottom: 1px solid var(--line); }
.steps li > span { display: grid; place-items: center; width: 28px; height: 28px; color: var(--white); background: var(--green); font: 700 12px/1 Arial, sans-serif; border-radius: 50%; }
.steps strong { display: block; margin-bottom: 2px; }
.steps p { margin: 0; color: var(--muted); font-size: 13px; }

.checklist-section { padding: clamp(72px, 10vw, 128px) 0; background: #e9e4db; }
.checklist-grid { display: grid; grid-template-columns: .8fr 1.2fr; gap: clamp(50px, 9vw, 130px); align-items: center; }
.checklist-grid > div:first-child > p:last-child { max-width: 430px; margin-top: 28px; color: var(--muted); font-size: 14px; }
.check-items { border-top: 1px solid rgba(20,33,39,.3); }
.check-items label { display: grid; grid-template-columns: 26px 1fr; gap: 18px; align-items: center; padding: 22px 0; border-bottom: 1px solid rgba(20,33,39,.3); cursor: pointer; }
.check-items input { width: 20px; height: 20px; margin: 0; accent-color: var(--green); }
.check-items span { color: var(--muted); font-size: 13px; }
.check-items strong { display: inline-block; min-width: 110px; color: var(--ink); font-size: 15px; }

.dm-section { position: relative; display: grid; place-items: center; min-height: 700px; overflow: hidden; color: var(--white); text-align: center; background: #0e171a; }
.dm-art, .dm-overlay { position: absolute; inset: 0; }
.dm-art img { width: 100%; height: 100%; object-fit: cover; object-position: 50% 52%; }
.dm-overlay { background: rgba(5,20,18,.77); }
.dm-content { position: relative; z-index: 1; width: min(820px, calc(100% - 40px)); padding: 72px 0; }
.dm-content .eyebrow::before { display: none; }
.dm-content h2 span { color: #f4d28f; }
.copy-keyword { display: inline-flex; gap: 12px; align-items: center; margin-top: 36px; padding: 14px 22px; color: var(--ink); background: var(--white); border: 0; border-radius: 2px; font-weight: 700; cursor: pointer; }
.copy-keyword:hover { background: #f4d28f; }
.copy-keyword:focus-visible, .header-cta:focus-visible, .text-link:focus-visible, .sticky-cta a:focus-visible { outline: 3px solid #f4d28f; outline-offset: 4px; }
.copy-icon { position: relative; display: block; width: 15px; height: 18px; border: 1px solid currentColor; }
.copy-icon::before { content: ""; position: absolute; top: -4px; left: 3px; width: 15px; height: 18px; border: 1px solid currentColor; }
.dm-note { max-width: 620px; margin: 24px auto 0; color: #b8c7c3; font-size: 12px; }

.site-footer { padding: 56px max(24px, calc((100vw - var(--max)) / 2)) 100px; color: #c7d0ce; background: #0b1516; }
.footer-inner { display: flex; gap: 28px; align-items: center; padding-bottom: 34px; border-bottom: 1px solid rgba(255,255,255,.13); }
.footer-brand { display: inline-flex; flex: 0 0 auto; gap: 10px; align-items: center; color: var(--white); }
.footer-brand img { width: 58px; height: 58px; object-fit: contain; }
.footer-inner p { margin: 0; }
.motto { color: var(--white); font-size: 17px; font-weight: 700; }
.clinic-name { margin-top: 6px !important; font: 700 12px/1.5 Arial, sans-serif; }
.legal-name { margin-top: 2px !important; font-size: 11px; }
.boundary { margin: 26px 0 0; color: var(--white); font-size: 13px; font-weight: 700; }
.local-note { margin: 8px 0 0; font-size: 10px; }

.sticky-cta { position: fixed; z-index: 20; right: 18px; bottom: 18px; display: flex; align-items: center; gap: 18px; padding: 9px 10px 9px 16px; color: var(--white); background: rgba(6,60,50,.95); box-shadow: 0 8px 28px rgba(0,0,0,.22); transition: opacity .2s, transform .2s; }
.sticky-cta[hidden] { display: none; }
.sticky-cta span { font-size: 18px; font-weight: 700; line-height: 1; }
.sticky-cta small { display: block; margin-bottom: 3px; font-size: 8px; font-weight: 500; }
.sticky-cta a { min-width: 0; padding: 9px 13px; color: var(--green-deep); background: var(--white); font-size: 12px; font-weight: 700; text-decoration: none; white-space: nowrap; }
.toast { position: fixed; z-index: 30; left: 50%; bottom: 28px; margin: 0; padding: 10px 16px; color: var(--white); background: var(--ink); font-size: 13px; opacity: 0; transform: translate(-50%, 16px); transition: .2s; pointer-events: none; }
.toast.is-visible { opacity: 1; transform: translate(-50%, 0); }

@media (max-width: 900px) {
  .site-header { grid-template-columns: 135px 1fr auto; min-height: 70px; padding-inline: 20px; }
  .brand { gap: 8px; }
  .brand img { width: 38px; height: 38px; }
  .brand-type strong { font-size: 11px; }
  .brand-type small { font-size: 6px; }
  .series-mark span { display: none; }
  .hero { min-height: 740px; }
  .hero-media img { object-position: 58% 50%; }
  .hero-shade { background: linear-gradient(0deg, rgba(8,15,18,.92) 0%, rgba(8,15,18,.65) 50%, rgba(8,15,18,.16) 100%); }
  .answer-grid, .inflammation-grid, .checklist-grid { grid-template-columns: 1fr; }
  .answer-note { max-width: 680px; }
  .split-section, .pathway-section { grid-template-columns: 1fr; }
  .split-media { min-height: 620px; }
  .pathway-image { min-height: 620px; }
  .pathway-copy { order: -1; }
  .section-heading { grid-template-columns: 1fr; }
  .evidence-row { grid-template-columns: .9fr 1.5fr .55fr; gap: 18px; }
}

@media (max-width: 620px) {
  .site-header { grid-template-columns: 1fr auto; }
  .series-mark { display: none; }
  .header-cta { font-size: 12px; }
  .hero { min-height: min(720px, 92svh); }
  .hero-media img { object-position: 58% 46%; }
  .hero-copy { width: calc(100% - 40px); margin: 0 20px 62px; padding: 0; }
  .hero h1 { font-size: clamp(28px, 8vw, 38px); }
  .mobile-only { display: block; }
  .section-inner { width: min(100% - 36px, var(--max)); }
  h2 { font-size: clamp(27px, 8.4vw, 38px); }
  .answer-band { padding-block: 72px; }
  .answer-grid { gap: 36px; }
  .split-media { min-height: 520px; }
  .split-copy, .pathway-copy { padding: 68px 20px; }
  .definition-list div { grid-template-columns: 54px 1fr; gap: 12px; }
  .inflammation-grid { gap: 40px; }
  .inflammation-figure img { max-height: 520px; }
  .section-heading { margin-bottom: 38px; }
  .evidence-head { display: none; }
  .evidence-row { display: grid; grid-template-columns: 1fr auto; gap: 12px; min-height: auto; padding: 24px 0; }
  .evidence-row > span:nth-child(2) { grid-column: 1 / -1; grid-row: 2; }
  .evidence-tag { grid-column: 2; grid-row: 1; }
  .pathway-image { min-height: 560px; }
  .checklist-grid { gap: 42px; }
  .check-items strong { display: block; min-width: 0; }
  .dm-section { min-height: 660px; }
  .footer-inner { align-items: flex-start; }
  .footer-inner { flex-wrap: wrap; }
  .footer-brand img { width: 48px; height: 48px; }
  .motto { font-size: 14px; }
  .sticky-cta { right: 10px; bottom: 10px; left: 10px; max-width: calc(100vw - 20px); gap: 10px; justify-content: space-between; padding-left: 12px; }
  .toast { bottom: 80px; white-space: nowrap; }
}

@media (prefers-reduced-motion: reduce) {
  html { scroll-behavior: auto; }
  *, *::before, *::after { transition-duration: .01ms !important; }
}